کمک هزینه تحصیلی پسادکتری (زیست شناسی، فیزیولوژی) در Medical Faculty Heidelberg آلمان

Postdoctoral Fellow at the Institute of Physiology and Pathophysiology

The Institute of Physiology and Pathophysiology is part of the Medical Faculty of Heidelberg University. The scientists of the Institute participate in various national and international collaborative research projects and teach the subject of physiology to about 450 students of medicine and dentistry annually. Research focuses on the physiology and pathophysiology of the cardiovascular, muscular and nervous system.
The Department of Cardiovascular Physiology at the Institute of Physiology and Pathophysiology (Prof. Dr. Markus Hecker) offers the following position, to be filled as soon as possible:
Postdoctoral Fellow (Wissenschaftlicher Mitarbeiter)
The position is funded by the German Research Foundation for an initial period of three years, with the possibility of an extension depending on the progress of the work.
Scientific Focus of the Department:

Research topics addressed include remodeling processes in the cardiovascular system induced by biomechanical factors, e. g., during hypertension and atherosclerosis, at all levels of signal transduction, the development of nucleic acid-based therapeutics for the treatment of heart failure, the interaction of endothelial cells with leucocytes and platelets during chronic inflammatory diseases, proteasome activity and its regulation in cardiac hypertrophy, reactive oxygen species as signaling molecules in diabetes, and the functional characterization of stem cell-derived cardiomyocytes and their cultivation as 3D cell patches for regenerative medicine. The knowledge gained hereby may serve as a basis for the development of novel molecular and cell biological therapies.
Your Project:

In conduit arteries a chronic rise in blood pressure increases wall tension and stretching of vascular smooth muscle cells, which respond with hypertrophy/hyperplasia and reorganization of the extracellular matrix. This project aims at elucidating the role the focal adhesions proteins zyxin and lipoma preferred partner (LPP), which ACT as mechanical transducers, play in this process. Particular focus will be on the activation and activity of these proteins and their interactions with other regulatory elements at the cell membrane, in the cytoplasm and the nucleus, and their possible mutual compensation if one of them is absent. To this end a combination of biochemical, molecular and cell biological techniques will be employed. Central part of the project is the analysis of knock-out and double knock-out mice, some of which will be generated within the framework of this project.
Your Qualifications:

You should have a PhD in cell biology, molecular biology, physiology or a related discipline. Profound knowledge in generating transgenic mouse models using the CRISPR/Cas9 genome editing technique, including designing the necessary constructs, is a must, experience in the transient in vitrotransduction of murine cells employing magneto- or nucleofection and/or adenoviral vectors a plus. You should also enjoy guiding and advising PhD and MD students who participate in the project.
Applications will be accepted until the position is filled.
Please send – preferentially by e-mail – your application, which should include a letter of motivation, a short description of your research background, your CV, your list of publications, and two letters of reference, to:
Prof. Dr. Markus Hecker, Universität Heidelberg, Institut für Physiologie und Pathophysiologie, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
E-Mail: sekretariat.hecker@physiologie.uni-heidelberg.de